{"id":645,"date":"2024-12-20T07:24:03","date_gmt":"2024-12-20T07:24:03","guid":{"rendered":"https:\/\/air-icu.com\/?p=645"},"modified":"2024-12-20T07:57:40","modified_gmt":"2024-12-20T07:57:40","slug":"the-use-of-an-inspiration-synchronized-vibrating-mesh-nebulizer-for-prolonged-inhalative-iloprost-administration-in-mechanically-ventilated-patients","status":"publish","type":"post","link":"https:\/\/air-icu.com\/cn\/the-use-of-an-inspiration-synchronized-vibrating-mesh-nebulizer-for-prolonged-inhalative-iloprost-administration-in-mechanically-ventilated-patients\/","title":{"rendered":"\u4f7f\u7528\u5438\u6c14\u540c\u6b65\u632f\u52a8\u7f51\u72b6\u96fe\u5316\u5668\u5bf9\u673a\u68b0\u901a\u6c14\u60a3\u8005\u5ef6\u957f\u5438\u5165\u4f0a\u6d1b\u524d\u5217\u7d20\u7ed9\u836f"},"content":{"rendered":"<!-- wp:paragraph {\"fontSize\":\"medium\"} -->\n<p class=\"has-medium-font-size\"><strong>\u6458\u8981<\/strong>\u60a3\u6709\u6025\u6027\u547c\u5438\u7a98\u8feb\u7efc\u5408\u5f81\uff08ARDS\uff09\u7684\u673a\u68b0\u901a\u6c14\u60a3\u8005\u7ecf\u5e38\u63a5\u53d7\u96fe\u5316\u4f0a\u6d1b\u524d\u5217\u7d20\u6cbb\u7597\u3002\u7531\u4e8e\u524d\u5217\u73af\u7d20\u534a\u8870\u671f\u77ed\uff0c\u5ef6\u957f\u5438\u5165\u65f6\u95f4\u53ef\u4ee5\u63d0\u9ad8\u5176\u4e34\u5e8a\u7597\u6548\uff0c\u4f46\u5b58\u5728\u6280\u672f\u56f0\u96be\u3002\u4e00\u79cd\u6f5c\u5728\u7684\u89e3\u51b3\u65b9\u6848\u662f\u4f7f\u7528\u5438\u6c14\u540c\u6b65\u632f\u52a8\u7f51\u72b6\u96fe\u5316\u5668 (VMNsyn)\uff0c\u5b83\u5177\u6709\u8f83\u9ad8\u7684\u836f\u7269\u6c89\u79ef\u7387\u548c\u8f83\u957f\u7684\u96fe\u5316\u65f6\u95f4\u3002\u7136\u800c\uff0c\u7f3a\u4e4f\u6bd4\u8f83\u957f\u65f6\u95f4\u96fe\u5316\u4e0e\u4f7f\u7528\u8fde\u7eed\u632f\u52a8\u7f51\u72b6\u96fe\u5316\u5668\uff08VMNcont\uff09\u63a8\u6ce8\u4f0a\u6d1b\u524d\u5217\u7d20\u7684\u6570\u636e\uff0c\u4ee5\u53ca\u68c0\u67e5\u4e0d\u540c\u901a\u6c14\u6a21\u5f0f\u5bf9\u5438\u6c14\u540c\u6b65\u96fe\u5316\u7684\u5f71\u54cd\u7684\u6570\u636e\u3002\u4e3a\u4e86\u89e3\u51b3\u8fd9\u4e00\u5dee\u8ddd\uff0c\u4f7f\u7528\u6210\u4eba\u673a\u68b0\u901a\u6c14\u6a21\u578b\u8fdb\u884c\u4e86\u4e00\u9879\u4f53\u5916\u7814\u7a76\uff0c\u6bd4\u8f83\u4e86\u5bb9\u91cf\u63a7\u5236 (VC-CMV) \u548c\u538b\u529b\u63a7\u5236\u6301\u7eed\u5f3a\u5236\u901a\u6c14 (PC-CMV) \u6a21\u5f0f\u4e0b\u7684 VMNsyn \u548c VMNcont\u3002\u8be5\u7814\u7a76\u8bc4\u4f30\u4e86\u4f0a\u6d1b\u524d\u5217\u7d20\u6c89\u79ef\u7387\u548c\u96fe\u5316\u65f6\u95f4\u3002\u5728VC-CMV\u6a21\u5f0f\u4e0b\uff0cVMNsyn\u7684\u6c89\u79ef\u7387\u4e0eVMNcont\u76f8\u4f3c\uff0c\u4f46\u5728PC-CMV\u6a21\u5f0f\u4e0b\u4f4e10.9%\u3002\u5728\u4e24\u79cd\u6a21\u5f0f\u4e0b\uff0cVMNsyn \u7684\u6c14\u96fe\u8f93\u51fa\u5747\u663e\u7740\u4f4e\u4e8e VMNcont\uff0c\u5bfc\u81f4 VC-CMV \u7684\u96fe\u5316\u65f6\u95f4\u5ef6\u957f 7.5 \u500d\uff0cPC-CMV \u7684\u96fe\u5316\u65f6\u95f4\u5ef6\u957f 4.2 \u500d\u3002\u56e0\u6b64\uff0cVC-CMV \u6a21\u5f0f\u4e0b\u7684\u5438\u6c14\u540c\u6b65\u96fe\u5316\u4f3c\u4e4e\u662f\u673a\u68b0\u901a\u6c14\u60a3\u8005\u957f\u65f6\u95f4\u5438\u5165\u4f0a\u6d1b\u524d\u5217\u7d20\u7684\u6700\u6709\u6548\u65b9\u6cd5\u3002<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:image {\"id\":646,\"sizeSlug\":\"large\",\"linkDestination\":\"none\",\"align\":\"center\"} -->\n<figure class=\"wp-block-image aligncenter size-large\"><img src=\"https:\/\/air-icu.com\/wp-content\/uploads\/2024\/12\/image-1024x576.jpg\" alt=\"\" class=\"wp-image-646\"><\/figure>\n<!-- \/wp:image -->\n\n<!-- wp:paragraph {\"fontSize\":\"medium\"} -->\n<p class=\"has-medium-font-size\"><strong>\u7b80\u4ecb<\/strong>\u6025\u6027\u547c\u5438\u7a98\u8feb\u7efc\u5408\u5f81\uff08ARDS\uff09\u7684\u7279\u70b9\u662f\u80ba\u8840\u7ba1\u529f\u80fd\u969c\u788d\uff0c\u5bfc\u81f4\u6025\u6027\u80ba\u52a8\u8109\u9ad8\u538b\u3001\u8fdb\u884c\u6027\u53f3\u5fc3\u8870\u7aed\u548c\u6025\u6027\u80ba\u6e90\u6027\u5fc3\u810f\u75c5\u3002\u6709\u591a\u79cd\u836f\u7269\u53ef\u7528\u4e8e\u6cbb\u7597\u6025\u6027\u53f3\u5fc3\u8870\u7aed\uff0c\u5176\u4e2d\u8bb8\u591a\u836f\u7269\u662f\u4ece\u539f\u53d1\u6027\u80ba\u52a8\u8109\u9ad8\u538b\uff08PPH\uff09\u7684\u6cbb\u7597\u4e2d\u91cd\u65b0\u5229\u7528\u7684\uff0c\u901a\u5e38\u901a\u8fc7\u53e3\u670d\u6216\u9759\u8109\u6ce8\u5c04\u7ed9\u836f\u3002\u7136\u800c\uff0c\u5168\u8eab\u7ed9\u836f\u5f80\u5f80\u7f3a\u4e4f\u80ba\u90e8\u9009\u62e9\u6027\uff0c\u5bfc\u81f4\u5168\u8eab\u8840\u7ba1\u8212\u5f20\u548c\u975e\u901a\u6c14\u80ba\u90e8\u533a\u57df\u80ba\u8840\u7ba1\u8212\u5f20\u7b49\u526f\u4f5c\u7528\uff0c\u4ece\u800c\u52a0\u91cd\u4f4e\u6c27\u8840\u75c7\u3002\u80ba\u90e8\u7ed9\u836f\u6709\u52a9\u4e8e\u51cf\u8f7b\u8fd9\u4e9b\u4e0d\u826f\u53cd\u5e94\uff0c\u524d\u5217\u73af\u7d20\u7c7b\u4f3c\u7269\u4f0a\u6d1b\u524d\u5217\u7d20\u5c31\u8bc1\u660e\u4e86\u8fd9\u4e00\u70b9\u3002<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph {\"fontSize\":\"medium\"} -->\n<p class=\"has-medium-font-size\">\u5728 ARDS \u60a3\u8005\u4e2d\uff0c\u96fe\u5316 5 \u00b5g \u4f0a\u6d1b\u524d\u5217\u7d20\u5df2\u88ab\u8bc1\u660e\u53ef\u4ee5\u6539\u5584\u6c27\u5408\uff0c\u800c\u4e0d\u4f1a\u663e\u7740\u964d\u4f4e\u5168\u8eab\u8840\u538b\u3002\u7136\u800c\uff0c\u5c1a\u65e0\u7814\u7a76\u8bc1\u660e\u6b64\u7c7b\u5e72\u9884\u63aa\u65bd\u53ef\u4ee5\u6539\u5584\u60a3\u8005\u7684\u6cbb\u7597\u7ed3\u679c\u3002\u4e00\u79cd\u53ef\u80fd\u7684\u89e3\u91ca\u662f\uff0c\u5728\u8fd9\u4e9b\u7814\u7a76\u4e2d\uff0c\u4f0a\u6d1b\u524d\u5217\u7d20\u662f\u901a\u8fc7\u8fde\u7eed\u96fe\u5316\u7ed9\u836f\u7684\uff0c\u5728\u77ed\u65f6\u95f4\u5185\u8f93\u9001\u5927\u91cf\u836f\u7269\u3002\u9274\u4e8e\u4f0a\u6d1b\u524d\u5217\u7d20\u7684\u534a\u8870\u671f\u4ece\u51e0\u5206\u949f\u5230\u6700\u957f30\u5206\u949f\u4e0d\u7b49\uff0c\u56e0\u6b64\u7ed9\u836f\u540e\u6cbb\u7597\u6548\u679c\u53ef\u80fd\u4f1a\u8fc5\u901f\u51cf\u5f31\u3002\u4e3a\u4e86\u89e3\u51b3\u8fd9\u4e2a\u95ee\u9898\uff0c\u6211\u4eec\u5bf9\u4e25\u91cd PPH \u60a3\u8005\u7684\u4f0a\u6d1b\u524d\u5217\u7d20\u5ef6\u957f\u9759\u8109\u8f93\u6ce8\u65b9\u6848\u8fdb\u884c\u4e86\u7814\u7a76\u3002\u4e3a\u4e86\u907f\u514d\u8840\u6d41\u52a8\u529b\u5b66\u4e0d\u7a33\u5b9a\u7684 ARDS \u60a3\u8005\u53d1\u751f\u5168\u8eab\u8840\u7ba1\u8212\u5f20\uff0c\u5ef6\u957f\u5438\u5165\u65b9\u6848\u66f4\u4e3a\u53ef\u53d6\u3002\u7136\u800c\uff0c\u8fd9\u79cd\u65b9\u6cd5\u5c1a\u672a\u7ecf\u8fc7\u4e34\u5e8a\u8bc4\u4f30\uff0c\u53ef\u80fd\u662f\u7531\u4e8e\u5e38\u89c4\u4e34\u5e8a\u5b9e\u8df5\u4e2d\u957f\u671f\u5438\u5165\u6c14\u96fe\u5242\u7ed9\u836f\u76f8\u5173\u7684\u6280\u672f\u6311\u6218<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph {\"fontSize\":\"medium\"} -->\n<p class=\"has-medium-font-size\">\u89e3\u51b3\u8fd9\u4e2a\u95ee\u9898\u7684\u4e00\u4e2a\u5b9e\u7528\u65b9\u6cd5\u662f\u4f7f\u7528\u5438\u6c14\u540c\u6b65\u632f\u52a8\u7f51\u72b6\u96fe\u5316\u5668 (VMNsyn)\uff0c\u8be5\u96fe\u5316\u5668\u5df2\u7528\u4e8e\u673a\u68b0\u901a\u6c14\u60a3\u8005\u96fe\u5316\u6297\u751f\u7d20\u3002\u901a\u8fc7\u5c06\u6c14\u96fe\u5242\u8f93\u9001\u4e0e\u5438\u6c14\u6c14\u6d41\u540c\u6b65\uff0cVMNsyn \u53ef\u4ee5\u5b9e\u73b0\u6bd4\u63a8\u6ce8\u8f93\u9001\u957f\u4e09\u5230\u4e5d\u500d\u7684\u96fe\u5316\u65f6\u95f4\uff0c\u540c\u65f6\u7531\u4e8e\u547c\u6c14\u8fc7\u7a0b\u4e2d\u836f\u7269\u635f\u5931\u51cf\u5c11\u800c\u4fdd\u6301\u76f8\u4f3c\u751a\u81f3\u66f4\u9ad8\u7684\u836f\u7269\u6c89\u79ef\u7387\u3002\u56e0\u6b64\uff0c\u5728\u4f53\u5916\u6a21\u578b\u4e2d\u673a\u68b0\u901a\u6c14\u6210\u4eba\u3001\u5438\u6c14\u540c\u6b65\u632f\u52a8\u7f51\u72b6\u96fe\u5316\u5668 (VMNsyn) \u548c\u8fde\u7eed\u632f\u52a8\u7f51\u72b6\u96fe\u5316\u5668\u7684\u836f\u7269\u6c89\u79ef\u7387\u548c\u96fe\u5316\u65f6\u95f4(VMNcont) \u5728\u4e24\u79cd\u57fa\u672c\u901a\u6c14\u6a21\u5f0f\u4e0b\u8fdb\u884c\u4e86\u6bd4\u8f83\uff1a(A) \u5bb9\u91cf\u63a7\u5236\u6301\u7eed\u6307\u4ee4\u901a\u6c14 (VC-CMV) \u548c (B) \u538b\u529b\u63a7\u5236\u6301\u7eed\u6307\u4ee4\u901a\u6c14 (PC-CMV)\u3002<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph {\"fontSize\":\"medium\"} -->\n<p class=\"has-medium-font-size\"><strong>\u7ed3\u679c\u548c\u7ed3\u8bba<\/strong>\u5728\u673a\u68b0\u901a\u6c14\u60a3\u8005\u7684\u4f53\u5916\u6a21\u578b\u4e2d\uff0cVC-CMV \u6a21\u5f0f\u4e0b\u4f7f\u7528\u7684\u4f20\u7edf\u5438\u6c14\u540c\u6b65\u632f\u52a8\u7f51\u72b6\u96fe\u5316\u5668 (VMNsyn) \u5b9e\u73b0\u4e86\u4e0e\u63a8\u6ce8\u7ed9\u836f\u76f8\u4f3c\u7684\u4f0a\u6d1b\u524d\u5217\u7d20\u6c89\u79ef\u7387\u4f7f\u7528\u8fde\u7eed\u96fe\u5316\u5668 (VMNcont)\uff0c\u540c\u65f6\u8fd8\u5c55\u793a\u4e86 7.5 \u500d\u7684\u96fe\u5316\u65f6\u95f4\u3002\u8fd9\u79cd\u8bbe\u7f6e\u4f3c\u4e4e\u9002\u5408\u673a\u68b0\u901a\u6c14\u60a3\u8005\u957f\u65f6\u95f4\u5438\u5165\u4f0a\u6d1b\u524d\u5217\u7d20\u3002<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph {\"fontSize\":\"medium\"} -->\n<p class=\"has-medium-font-size\">\u7136\u800c\uff0c\u5728PC-CMV\u6a21\u5f0f\u4e0b\uff0cVMNsyn\u7684\u6c89\u79ef\u7387\u663e\u7740\u964d\u4f4e\uff0c\u96fe\u5316\u65f6\u95f4\u663e\u7740\u7f29\u77ed\uff0c\u7834\u574f\u4e86\u9884\u671f\u7684\u5ef6\u957f\u7ed9\u836f\u65f6\u95f4\u5e76\u6700\u5927\u9650\u5ea6\u5730\u51cf\u5c11\u4e86\u4f0a\u6d1b\u524d\u5217\u7d20\u7684\u6f5c\u5728\u76ca\u5904\u3002\u56e0\u6b64\uff0c\u5546\u4e1aVMNsyn\u6a21\u578b\u7684\u672a\u6765\u53d1\u5c55\u5e94\u4fa7\u91cd\u4e8e\u4f18\u5316\u5438\u6c14\u521d\u59cb\u9636\u6bb5\u7684\u6c14\u6eb6\u80f6\u91ca\u653e\u3002\u8fd9\u5c06\u4f7f\u6c89\u79ef\u901f\u7387\u548c\u96fe\u5316\u65f6\u95f4\u66f4\u5c11\u5730\u4f9d\u8d56\u4e8e\u901a\u6c14\u6a21\u5f0f\uff0c\u4ece\u800c\u4f7f VMNsyn \u80fd\u591f\u6700\u5927\u9650\u5ea6\u5730\u53d1\u6325\u5176\u8282\u7701\u836f\u7269\u7684\u6f5c\u529b\uff0c\u5e76\u5b9e\u73b0\u6bd4 VMNcont \u66f4\u9ad8\u7684\u6c89\u79ef\u901f\u7387\u3002<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph {\"fontSize\":\"medium\"} -->\n<p class=\"has-medium-font-size\">\u7136\u800c\uff0c\u957f\u671f\u5438\u5165\u4f0a\u6d1b\u524d\u5217\u7d20\u4e0e VMNsyn \u5bf9\u836f\u4ee3\u52a8\u529b\u5b66\u548c\u6cbb\u7597\u7ed3\u679c\u7684\u5f71\u54cd\u4ecd\u9700\u8981\u4e34\u5e8a\u8bd5\u9a8c\u7814\u7a76\u3002\u4e00\u9879\u9488\u5bf9\u673a\u68b0\u901a\u6c14 ARDS \u60a3\u8005\u7684\u968f\u673a\u4ea4\u53c9\u7814\u7a76\u53ef\u4ee5\u63d0\u4f9b\u4e0e\u63a8\u6ce8\u96fe\u5316\u76f8\u6bd4\uff0c\u957f\u671f\u80ba\u4f0a\u6d1b\u524d\u5217\u7d20\u7ed9\u836f\u5bf9\u836f\u4ee3\u52a8\u529b\u5b66\u3001\u80ba\u8840\u7ba1\u963b\u529b\u3001\u53f3\u5fc3\u529f\u80fd\u3001\u6c27\u5408\u548c\u8840\u6d41\u52a8\u529b\u5b66\u7684\u5f71\u54cd\u7684\u6709\u4ef7\u503c\u7684\u89c1\u89e3\u3002<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p><\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p><strong>\u53c2\u8003<\/strong><\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>[1]\u4ef7\u683c\uff0cLC\uff1b\u9ea6\u8003\u5229\uff0cD.F.\uff1b\u9a6c\u91cc\u8bfa\uff0cP.S.\uff1b\u82ac\u5c3c\uff0cS.J.\uff1b\u683c\u91cc\u83f2\u65af\uff0cM.J.\uff1b\u6c83\u7279\uff0cS.J.\u6025\u6027\u80ba\u635f\u4f24\u80ba\u52a8\u8109\u9ad8\u538b\u7684\u75c5\u7406\u751f\u7406\u5b66\u3002\u662f\u3002 J.\u751f\u7406\u5b66\u3002\u80ba\u7ec6\u80de\u5206\u5b50\u3002\u751f\u7406\u5b66\u3002 2012, 302, L803\u2013L815\u3002 [2]\u5e03\u5c14\uff0cT.M.\uff1b\u514b\u62c9\u514b\uff0cB.\uff1b\u9ea6\u514b\u8303\uff0cK.\uff1b Moss, M. \u80ba\u8840\u7ba1\u529f\u80fd\u969c\u788d\u4e0e\u6025\u6027\u80ba\u635f\u4f24\u60a3\u8005\u7684\u4e0d\u826f\u9884\u540e\u76f8\u5173\u3002\u662f\u3002 J.\u547c\u5438\u3002\u66b4\u51fb\u3002\u62a4\u7406\u533b\u5b66\u3002 2010, 182, 1123\u20131128.[3]Mekontso Dessap, A.\uff1b\u5e03\u74e6\u897f\u8036\uff0cF.\uff1b\u5361\u4f26\uff0cC.\uff1b\u8d1d\u6208\u7279\uff0cE.\uff1b\u96f7\u4f69\u585e\uff0cX.\uff1b\u83b1\u683c\u62c9\u65af\uff0cA.\uff1b\u5e03\u4f26-\u6bd4\u677e\uff0cC.\uff1b\u7ef4\u5c3c\u7fc1\uff0cP.\uff1b Vieillard-Baron, A. \u6025\u6027\u547c\u5438\u7a98\u8feb\u7efc\u5408\u5f81\u4fdd\u62a4\u6027\u901a\u6c14\u671f\u95f4\u7684\u6025\u6027\u80ba\u5fc3\u75c5\uff1a\u60a3\u75c5\u7387\u3001\u9884\u6d4b\u56e0\u7d20\u548c\u4e34\u5e8a\u5f71\u54cd\u3002\u91cd\u75c7\u76d1\u62a4\u533b\u5b66\u3002 2016, 42, 862\u2013870\u3002 [4]\u52a0\u5185\u91cc\u74e6\u5c14\uff0cS.\uff1b\u963f\u5c14\u7ef4\u65af\u00b7\u591a\u65af\u00b7\u5b89\u970d\u65af\uff0cG.\uff1b\u65bd\u83b1\u6b47\u5c14\uff0cM.\uff1b\u970d\u514b\u65af\u5766\uff0c\u6587\u5b66\u7855\u58eb\uff1b\u6258\u5185\u5229\uff0cA.R.\uff1b\u675c\u683c\u5c14\uff0cA.\uff1b\u897f\u4e4c\u5df4\uff0cM.T.\u6025\u6027\u547c\u5438\u7a98\u8feb\u7efc\u5408\u5f81\u7684\u53f3\u5fc3\u5ba4\u7279\u5f02\u6027\u6cbb\u7597\uff1a\u8303\u56f4\u754c\u5b9a\u5ba1\u67e5\u3002\u66b4\u51fb\u3002\u62a4\u7406 2023, 27, 104\u3002 [5]Ymeraj, S.\uff1b\u963f\u56fe\uff0cR.\uff1b Redant, S. 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