{"id":485,"date":"2024-11-28T10:09:39","date_gmt":"2024-11-28T10:09:39","guid":{"rendered":"https:\/\/air-icu.com\/?p=485"},"modified":"2024-11-29T02:56:04","modified_gmt":"2024-11-29T02:56:04","slug":"pulmonary-drug-delivery-using-continuous-and-inspiratory-synchronized-vibrating-mesh-nebulization-during-noninvasive-ventilation-in-healthy-subjects","status":"publish","type":"post","link":"https:\/\/air-icu.com\/cn\/pulmonary-drug-delivery-using-continuous-and-inspiratory-synchronized-vibrating-mesh-nebulization-during-noninvasive-ventilation-in-healthy-subjects\/","title":{"rendered":"\u5728\u5065\u5eb7\u53d7\u8bd5\u8005\u65e0\u521b\u901a\u6c14\u671f\u95f4\u4f7f\u7528\u8fde\u7eed\u548c\u5438\u6c14\u540c\u6b65\u632f\u52a8\u7f51\u72b6\u96fe\u5316\u8fdb\u884c\u80ba\u90e8\u836f\u7269\u8f93\u9001"},"content":{"rendered":"<!-- wp:paragraph -->\n<p><\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>\u80cc\u666f\uff1a\u5355\u80a2\u56de\u8def\u53cc\u6c34\u5e73\u547c\u5438\u673a\u76ee\u524d\u65e0\u6cd5\u4f7f\u7528\u547c\u5438\u540c\u6b65\u96fe\u5316\u9009\u9879\uff0c\u8be5\u9009\u9879\u53ef\u80fd\u4f1a\u6539\u5584\u65e0\u521b\u6b63\u538b\u901a\u6c14 (NIPPV) \u671f\u95f4\u7684\u836f\u7269\u8f93\u9001\u3002\u672c\u7814\u7a76\u7684\u76ee\u7684\u662f\u6bd4\u8f83\u4f7f\u7528\u4f20\u7edf\u8fde\u7eed (Conti-Neb) \u548c\u5b9e\u9a8c\u5438\u6c14\u540c\u6b65 (Inspi-Neb) \u96fe\u5316\u6a21\u5f0f\uff0c\u4e0e\u5355\u80a2\u56de\u8def\u53cc\u6c34\u5e73\u547c\u5438\u673a\u8054\u7528\u7684\u632f\u52a8\u7f51\u72b6\u96fe\u5316\u5668\u6c14\u96fe\u8f93\u9001\u540e\u963f\u7c73\u5361\u661f\u7684\u5c3f\u6392\u6cc4\u60c5\u51b5\u3002<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:image {\"id\":486,\"sizeSlug\":\"full\",\"linkDestination\":\"none\"} -->\n<figure class=\"wp-block-image size-full\"><img src=\"https:\/\/air-icu.com\/wp-content\/uploads\/2024\/11\/\u5fae\u4fe1\u56fe\u7247_20241128180616.png\" alt=\"\" class=\"wp-image-486\"><\/figure>\n<!-- \/wp:image -->\n\n<!-- wp:paragraph -->\n<p>\u6750\u6599\u548c\u65b9\u6cd5\uff1a\u8fdb\u884c\u4e86\u4e00\u9879\u4ea4\u53c9\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u6d89\u53ca 6 \u540d\u65e0\u521b\u901a\u6c14\u5065\u5eb7\u5fd7\u613f\u8005\uff08\u5e73\u5747\u5e74\u9f84 32.3 \u00b1 9.5 \u5c81\uff09\uff0c\u968f\u673a\u5206\u914d\u5230\u4e24\u79cd\u632f\u52a8\u7f51\u96fe\u5316\u6a21\u5f0f\uff1aInspi-Neb \u4ec5\u5728\u6574\u4e2a\u5438\u6c14\u9636\u6bb5\u8f93\u9001\u6c14\u96fe\u5242\uff0c\u800c Conti-Neb\u8fde\u7eed\u8f93\u9001\u6c14\u6eb6\u80f6\u3002\u6240\u6709\u53d7\u8bd5\u8005\u5728 NIPPV \u671f\u95f4\u4f7f\u7528\u5355\u80a2\u53cc\u6c34\u5e73\u547c\u5438\u673a\uff08\u5438\u6c14\u6c14\u9053\u6b63\u538b\uff1a12 cm H2O\uff0c\u547c\u6c14\u6c14\u9053\u6b63\u538b\uff1a5 cm H2O\uff09\u5438\u5165\u963f\u7c73\u5361\u661f\u6eb6\u6db2\uff08500 mg\/4 mL\uff09\u3002\u901a\u8fc7\u5438\u5165\u540e 24 \u5c0f\u65f6\u836f\u7269\u7684\u5c3f\u6db2\u6392\u6cc4\u6765\u6bd4\u8f83\u4e24\u79cd\u96fe\u5316\u6a21\u5f0f\u4e0b\u963f\u7c73\u5361\u661f\u7684\u80ba\u90e8\u836f\u7269\u9012\u9001\u3002<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>\u7ed3\u679c\uff1aInspi-Neb \u7ec4\u6bcf\u65e5\u5c3f\u6db2\u4e2d\u963f\u7c73\u5361\u661f\u6392\u6cc4\u603b\u91cf\uff08\u4e2d\u4f4d\u503c\uff1a44.72 mg\uff1b\u56db\u5206\u4f4d\u8ddd [IQR]\uff1a40.50-65.13\uff09\u663e\u7740\u9ad8\u4e8e Conti-Neb \u7ec4\uff08\u4e2d\u4f4d\u503c\uff1a40.07 mg\uff1bIQR\uff1a31.00-31.00-\uff09\u3002 43.73\uff09\uff0c\uff08p = 0.02\uff09\u3002 Inspi-Neb \u7684\u963f\u7c73\u5361\u661f\u6d88\u9664\u901f\u7387\u5e38\u6570\uff08\u95f4\u63a5\u6d4b\u91cf\u836f\u7269\u6e17\u900f\u5230\u80ba\u90e8\u7684\u6df1\u5ea6\uff09\uff08\u4e2d\u4f4d\u6570\uff1a0.137\uff1bIQR\uff1a0.113-0.146\uff09\u663e\u7740\u9ad8\u4e8e Conti-Neb\uff08\u4e2d\u4f4d\u6570\uff1a0.116\uff1bIQR\uff1a0.105\uff09 -0.130\uff09\uff0c\uff08p = 0.02\uff09\u3002\u7136\u800c\uff0cConti-Neb (2.03 mg\/min) \u7ec4\u7684\u5e73\u5747\u80ba\u90e8\u836f\u7269\u8f93\u9001\u7387\uff08\u4ee5\u963f\u7c73\u5361\u661f\u6bcf\u65e5\u5c3f\u603b\u91cf\u4e0e\u96fe\u5316\u65f6\u95f4\u4e4b\u6bd4\u8868\u793a\uff09\u663e\u7740\u9ad8\u4e8e Inspi-Neb (1.09 mg\/min) (p &lt; 0.01\uff09\u3002<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>\u7ed3\u8bba\uff1a\u5728\u4f7f\u7528\u5355\u80a2\u56de\u8def\u53cc\u6c34\u5e73\u547c\u5438\u673a\u8fdb\u884c NIPPV \u671f\u95f4\uff0c\u4e0e\u4f20\u7edf\u7684\u8fde\u7eed\u632f\u52a8\u7f51\u72b6\u96fe\u5316\u76f8\u6bd4\uff0c\u4f7f\u7528\u5438\u6c14\u540c\u6b65\u632f\u52a8\u7f51\u72b6\u96fe\u5316\u53ef\u4ee5\u6539\u5584\u80ba\u90e8\u836f\u7269\u8f93\u9001\u3002<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>\u53c2\u8003<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph {\"fontSize\":\"small\"} -->\n<p class=\"has-small-font-size\">Jean-Bernard Michotte\u3001Enrico Staderini\u3001Anne-Sophie Aubriot\u3001Emilie Jossen\u3001Jonathan Dugernier\u3001Giuseppe Liistro \u548c Gregory Reychler\uff1a\u5065\u5eb7\u5fd7\u613f\u8005\u65e0\u521b\u901a\u6c14\u671f\u95f4\u8fde\u7eed\u632f\u52a8\u7f51\u72b6\u96fe\u5316\u548c\u5438\u6c14\u540c\u6b65\u632f\u52a8\u7f51\u72b6\u96fe\u5316\u540e\u7684\u80ba\u90e8\u836f\u7269\u8f93\u9001\u3002<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p><\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph {\"fontSize\":\"small\"} -->\n<p class=\"has-small-font-size\"><\/p>\n<!-- \/wp:paragraph -->","protected":false},"excerpt":{"rendered":"\u5355\u80a2\u56de\u8def\u53cc\u6c34\u5e73\u547c\u5438\u673a\u76ee\u524d\u65e0\u6cd5\u4f7f\u7528\u547c\u5438\u540c\u6b65\u96fe\u5316\u9009\u9879\uff0c\u8be5\u9009\u9879\u53ef\u80fd\u4f1a\u6539\u5584\u65e0\u521b\u6b63\u538b\u901a\u6c14 (NIPPV) 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