{"id":164,"date":"2024-07-25T03:03:25","date_gmt":"2024-07-25T03:03:25","guid":{"rendered":"https:\/\/air-icu.com\/?p=164"},"modified":"2024-08-25T09:41:44","modified_gmt":"2024-08-25T09:41:44","slug":"clinical-evidence-for-nasal-aerosol-inhalation","status":"publish","type":"post","link":"https:\/\/air-icu.com\/cn\/clinical-evidence-for-nasal-aerosol-inhalation\/","title":{"rendered":"\u9f3b\u6c14\u96fe\u5438\u5165\u7684\u4e34\u5e8a\u8bc1\u636e"},"content":{"rendered":"\n
\u9f3b\u6c14\u96fe\u5438\u5165\u8d8a\u6765\u8d8a\u591a\u5730\u7528\u4e8e\u91cd\u75c7\u76d1\u62a4\u75c5\u623f (ICU)\u3002\u5728\u7f8e\u56fd\u513f\u79d1\u75c5\u623f\uff0c75%\u7684\u60a3\u8005\u63a5\u53d7\u9f3b\u96fe\u5316\u5438\u5165\u6cbb\u7597\uff0c\u5176\u4f59\u5219\u91c7\u7528\u4f20\u7edf\u96fe\u5316\u65b9\u6cd5\u3002<\/p>\n\n\n\n
\u5bf9\u4e8e\u4e25\u91cd\u4f4e\u6c27\u8840\u75c7\u7684\u60a3\u8005\uff0c\u5e38\u89c4\u4f7f\u7528\u9ad8\u6d41\u91cf\u7ecf\u9f3b\u6c27\u7597\uff08HFNC\uff09\u6709\u52a9\u4e8e\u6539\u5584\u6c27\u5408\uff0c\u6700\u7ec8\u907f\u514d\u63d2\u7ba1\u6216\u518d\u6b21\u63d2\u7ba1\u3002 HFNC\u9f3b\u6c14\u96fe\u5438\u5165\u7ed3\u5408\u4e86HFNC\u548c\u6c14\u96fe\u7597\u6cd5\u7684\u4f18\u70b9\u3002<\/p>\n\n\n\n
\u81ea2008\u5e74\u4ee5\u6765\uff0c\u4f53\u5185\/\u4f53\u5916\u7814\u7a76\u63a2\u7d22\u4e86\u5f71\u54cdHFNC\u6c14\u96fe\u5438\u5165\u6548\u679c\u7684\u591a\u79cd\u56e0\u7d20\u4ee5\u53ca\u9f3b\u8154\u6c14\u96fe\u5438\u5165\u9014\u5f84\u7684\u4e34\u5e8a\u6709\u6548\u6027\u3002<\/p>\n\n\n\n
2018 \u5e74\uff0cBraunlich \u7b49\u4eba\u3002\u7814\u7a76\u4e86 26 \u540d\u7a33\u5b9a\u671f\u6162\u6027\u963b\u585e\u6027\u80ba\u75be\u75c5 (COPD) \u60a3\u8005\uff0c\u53d1\u73b0 HFNC\uff08TNI Medical AG\uff0c\u5fb7\u56fd\uff09\u7ed3\u5408 35 L\/min \u6c14\u6d41\uff0c\u4e0e\u5438\u5165 2.5 mg \u6c99\u4e01\u80fa\u9187\u548c 0.5 mg \u5f02\u4e19\u6258\u6eb4\u94f5\u76f8\u6bd4\uff0c\u5177\u6709\u76f8\u4f3c\u7684\u652f\u6c14\u7ba1\u6269\u5f20\u4f5c\u7528\u3002\u5c0f\u5bb9\u91cf\u55b7\u5c04\u96fe\u5316\u5668 (JN) (P=0.5)\u3002\u540c\u6837\uff0cReMiniac \u7b49\u4eba\u3002\u7814\u7a76\u4e86 25 \u540d\u60a3\u6709\u53ef\u9006\u6027\u6c14\u6d41\u963b\u585e\u7684\u7a33\u5b9a\u60a3\u8005\uff0c\u53d1\u73b0 HFNC\uff08Airvo2\uff0c\u65b0\u897f\u5170\uff09\u8054\u5408\u632f\u52a8\u7f51\u72b6\u96fe\u5316\u5668 (VMN)\uff08Aerogen Solo\uff0c\u7231\u5c14\u5170\uff09\u96fe\u5316\u6cbb\u7597\u5bf9\u7b2c\u4e00\u79d2\u7528\u529b\u547c\u6c14\u91cf (FEV1) \u5177\u6709\u76f8\u5f53\u7684\u6539\u5584\u4e0e\u901a\u8fc7\u9762\u7f69 JN \u5438\u5165 2.5 mg \u6c99\u4e01\u80fa\u9187\u76f8\u6bd4\uff08P=0.11\uff09\u3002\u9ea6\u5fb7\u5c3c\u7b49\u4eba\u3002\u5728\u4e00\u9879\u5bf9 12 \u540d\u7a33\u5b9a\u671f COPD \u60a3\u8005\u8fdb\u884c\u7684\u4ea4\u53c9\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u4e2d\uff0c\u6bd4\u8f83\u4e86\u4ee5 5 L\/min \u7684\u6d41\u901f\u5438\u5165 JN \u6216 VMN \u4e0e HFNC \u540e\u6c99\u4e01\u80fa\u9187\u7684\u751f\u7269\u5229\u7528\u5ea6\u3002\u7ed3\u679c\u663e\u793a\uff0c30\u5206\u949f\u548c24\u5c0f\u65f6\u540e\uff0cVMN\u7ec4\u5c3f\u6c99\u4e01\u80fa\u9187\u6392\u6cc4\u91cf\u662fJN\u7ec4\u76842\u500d\uff08P<0.05\uff09\u3002<\/p>\n\n\n\n \u5728\u7f8e\u56fd\u548c\u6b27\u6d32\uff0c\u6c99\u4e01\u80fa\u9187\u6eb6\u6db2\u7684\u6807\u7b7e\u5242\u91cf\u4e3a2.5\u6beb\u514b\u3002\u674e\u7b49\u4eba\u3002\u5bf9 42 \u540d\u7a33\u5b9a\u671f\u54ee\u5598\u6216 COPD \u60a3\u8005\u8fdb\u884c\u4e86\u5242\u91cf\u53cd\u5e94\u5206\u6790\u3002\u5df2\u77e5\u8fd9\u4e9b\u60a3\u8005\u5bf9\u901a\u8fc7\u8ba1\u91cf\u5438\u5165\u5668 (MDI) \u7ed3\u5408\u96fe\u5316\u5668 (SPACER) \u5438\u5165 400 \u5fae\u514b\u6c99\u4e01\u80fa\u9187\u6709\u53cd\u5e94\u3002\u53d7\u8bd5\u8005\u901a\u8fc7 HFNC \u7ed3\u5408 VMN \u4ee5 15 \u81f3 20 L\/min \u7684\u6c14\u6d41\u5438\u5165\u5242\u91cf\u9010\u6e10\u589e\u52a0\u7684\u6c99\u4e01\u80fa\u9187\u3002\u5f53\u6c99\u4e01\u80fa\u9187\u7d2f\u79ef\u5242\u91cf\u8fbe\u52301.5 mg\u65f6\uff0cHFNC\u8054\u5408VMN\u5bf9FEV1\u7684\u6539\u5584\u4e0eMDI\u8054\u5408SPACER\u76f8\u5f53\uff08P=0.878\uff09\uff08\u56fe1\uff09\u3002<\/p>\n\n\n\n \u5438\u5165\u524d\u5217\u73af\u7d20\u662f\u4e00\u79cd\u80ba\u8840\u7ba1\u6269\u5f20\u5242\uff0c\u53ef\u7528\u4e8e\u6cbb\u7597\u9700\u8981\u673a\u68b0\u901a\u6c14\u7684\u80ba\u52a8\u8109\u9ad8\u538b\u548c\/\u6216\u96be\u6cbb\u6027\u4f4e\u6c27\u8840\u75c7\u60a3\u8005\u3002\u4e24\u9879\u5c0f\u578b\u56de\u987e\u6027\u7814\u7a76\u53d1\u73b0\uff0c\u60a3\u6709\u80ba\u52a8\u8109\u9ad8\u538b\u548c\u96be\u6cbb\u6027\u4f4e\u6c27\u8840\u75c7\u7684\u6210\u5e74\u60a3\u8005\u5728\u4ee5 40 L\/min \u7684 HFNC \u6c14\u6d41\u5438\u5165\u524d\u5217\u73af\u7d20\u540e\u6c27\u5408\u5f97\u5230\u6539\u5584\u3002\u4e0e\u6052\u5b9a\u7684 HFNC \u6c14\u6d41\u76f8\u6bd4\uff0c\u6839\u636e\u60a3\u8005\u5bf9\u524d\u5217\u73af\u7d20\u7684\u53cd\u5e94\u5bf9 HFNC \u6c14\u6d41\u8fdb\u884c\u5e8a\u8fb9\u4e2a\u6027\u5316\u6ef4\u5b9a\u53ef\u6709\u6548\u964d\u4f4e\u5e73\u5747\u80ba\u52a8\u8109\u538b\u3002\u672a\u6765\u9700\u8981\u66f4\u5927\u6837\u672c\u91cf\u7684\u524d\u77bb\u6027\u7814\u7a76\u6765\u9a8c\u8bc1\u8fd9\u4e00\u53d1\u73b0\u3002<\/p>\n\n\n\n 2015 \u5e74\uff0c\u6469\u6839\u7b49\u4eba\u3002\u5bf9 5 \u540d\u5a74\u513f\u8fdb\u884c\u7814\u7a76\uff0c\u53d1\u73b0\u60a3\u6709\u6025\u6027\u7ec6\u652f\u6c14\u7ba1\u708e\u548c\u547c\u5438\u56f0\u96be\u7684\u513f\u7ae5\u5bf9 JN \u9762\u7f69\u96fe\u5316\u6cbb\u7597\u6ca1\u6709\u53cd\u5e94\u3002\u7136\u800c\uff0c\u901a\u8fc7HFNC\u8054\u5408VMN\u5438\u5165\u6c99\u4e01\u80fa\u9187\u540e\uff0c\u5a74\u513f\u8868\u73b0\u51fa\u826f\u597d\u7684\u8212\u9002\u5ea6\uff0c\u8fd9\u8868\u660e\u6c99\u4e01\u80fa\u9187\u4e0eHFNC\u8054\u5408\u53ef\u4ee5\u4f7f\u60a3\u8005\u53d7\u76ca\u3002\u4e0e\u9762\u7f69\u96fe\u5316\u5438\u5165\u8054\u5408VMN\u76f8\u6bd4\uff0cHFNC\u8054\u5408VMN\u7ec4\u60a3\u8005\u5fc3\u7387\u663e\u7740\u5347\u9ad8\uff08P<0.001\uff09\u3002\u5fc3\u7387\u663e\u7740\u589e\u52a0\u7684\u539f\u56e0\u53ef\u80fd\u662fHFNC\u8054\u5408VMN\u5438\u5165\u6c99\u4e01\u80fa\u9187\u7684\u5242\u91cf\u8f83\u9ad8\u3002\u4e0e\u9762\u7f69\u8054\u5408JN\u76f8\u6bd4\uff0cHFNC\uff08\u7ea68 L\/min\uff09\u8054\u5408VMN\u6c99\u4e01\u80fa\u9187\u96fe\u5316\u540e\u60a3\u8005\u7684\u8212\u9002\u5ea6\u548c\u6ee1\u610f\u5ea6\u663e\u7740\u63d0\u9ad8\u3002\u5bf9 39 \u4f8b\u672a\u63a5\u53d7 JN \u96fe\u5316\u6c99\u4e01\u80fa\u9187\u6cbb\u7597\u7684\u54ee\u5598\u6301\u7eed\u72b6\u6001\u513f\u7ae5\uff08\u5176\u4e2d 10 \u4f8b\u6709\u4e25\u91cd\u9178\u4e2d\u6bd2\uff0cpH < 7.30\uff09\u7684\u56de\u987e\u6027\u5206\u6790\u53d1\u73b0\uff0cHFNC \u95f4\u6b47\u7ed9\u836f\u6c99\u4e01\u80fa\u9187\u7684\u6700\u5927\u6c14\u6d41\u4e3a 1.0\uff080.8-1.1\uff09L\/kg\/ min\uff0c\u8fd9\u662f\u907f\u514d\u6c14\u7ba1\u63d2\u7ba1\u7684\u539f\u56e0\u4e4b\u4e00\u3002<\/p>\n\n\n\n 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\u6210\u4eba\u60a3\u8005 - \u901a\u8fc7 HFNC \u5438\u5165\u524d\u5217\u73af\u7d20<\/h2>\n\n\n\n
\u513f\u79d1\u60a3\u8005 - \u901a\u8fc7 HFNC \u5438\u5165\u6c99\u4e01\u80fa\u9187 <\/h2>\n\n\n\n
\u6982\u62ec <\/h2>\n\n\n\n