AbstractMechanically ventilated patients with acute respiratory distress syndrome (ARDS) often receive aerosolized iloprost. Due to the short half-life of prostacyclin, extending the duration of inhalation could enhance its clinical effectiveness, though this presents technical difficulties. One potential solution is the use of inspiration-synchronized vibrating mesh nebulizers (VMNsyn), which offer high drug deposition rates and prolonged […]
Background: A breath-synchronized nebulization option that could potentially improve drug delivery during noninvasive positive pressure ventilation (NIPPV) is currently not available on single-limb circuit bilevel ventilators. The aim of this study was to compare urinary excretion of amikacin following aerosol delivery with a vibrating mesh nebulizer coupled to a single-limb circuit bilevel ventilator, using conventional […]
Introduction Chronic obstructive pulmonary disease (COPD) is a progressive lung condition resulting from damage caused by harmful chemicals. These chemicals trigger a series of inflammatory responses that not only harm lung structure but also increase mucus production in the airways. COPD is characterized as a partially reversible condition with restricted airflow, leading to permanent damage […]
Aerosol administration during noninvasive ventilation (NIV) is a common clinical drug administration method, but the drug administration efficiency of different drug delivery devices is different.
Due to the characteristics of the lung tissue itself, the speed of lung absorption is very fast, no less than intravenous injection, such as isoproterenol aerosol can play a role in asthma 1-2min after inhalation.
When JN is used in combination with HFNC, the total gas flow in the HFNC system is greater than 6 L/min, which is also the minimum flow rate for running JN.
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